Coriolus Polysaccharides Extraction Methods

The extraction processes for PSP (Polysaccharopeptide) and PSK (Polysaccharide Krestin) involve obtaining specific polysaccharides from mushrooms, and while the exact details of proprietary extraction methods may vary among manufacturers, here is a general overview of how PSP and PSK are commonly extracted:

Extraction of PSP:

  1. Source Mushroom: PSP is often derived from the Coriolus versicolor mushroom, specifically the COV-1 strain. This strain is selected for its unique properties and the presence of polysaccharopeptides with potential health benefits.
  2. Cultivation: The mushrooms are cultivated in controlled environments, often using specialized substrates and cultivation conditions to optimize the production of bioactive compounds.
  3. Harvesting: Once the mushrooms have reached the desired maturity, they are harvested. The timing of harvest can impact the composition of bioactive compounds in the mushrooms.
  4. Extraction Process: The extraction of PSP typically involves a combination of physical, chemical, and/or enzymatic processes. These processes aim to break down the cell walls of the mushrooms and release the polysaccharopeptides into a liquid or powder form.
  5. Purification: The extracted material may undergo purification steps to isolate and concentrate the specific polysaccharopeptides associated with the desired health benefits.
  6. Drying: The purified extract is often dried to create a stable and concentrated form suitable for formulation into supplements.


Extraction of PSK:

  1. Source Mushroom: PSK is derived from the Coriolus versicolor mushroom, commonly known as Turkey Tail. The mycelium of the mushroom is typically used in the extraction process.
  2. Cultivation: The mycelium is cultivated in controlled environments, similar to the cultivation process for PSP.
  3. Harvesting: Once the mycelium has grown sufficiently, it is harvested. The mycelium contains the bioactive compounds, including polysaccharides like PSK.
  4. Extraction Process: The extraction process for PSK involves breaking down the cell walls of the mycelium to release the polysaccharides. This can be achieved through various methods, including hot water extraction or other solvent-based methods.
  5. Purification: Similar to PSP, the extracted material may undergo purification to isolate and concentrate the specific polysaccharides associated with PSK.
  6. Drying: The purified PSK extract is dried to create a stable and concentrated form suitable for use in supplements. Both PSP and PSK extraction processes aim to concentrate the beneficial polysaccharides from the mushrooms in a form that can be easily incorporated into supplements. The specific details of the extraction methods may vary among manufacturers, and proprietary techniques are often closely guarded. Additionally, adherence to quality standards and rigorous testing is crucial to ensure the purity and efficacy of the final extracts. 
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Used extensively across Asia
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